Variation in the Interleukin 4-Receptor a Gene 
Confers Susceptibility to Asthma and Atopy 
in Ethnically Diverse Populations 

Carole Ober et al.
 


Results of TDT with 2-locus haplotypes and asthma 
and +SPT in the Hutterites 

Haplotype 1 is composed of alleles 1-1
Haplotype 2 is composed of alleles 1-2 
Haplotype 3 is composed of alleles 2-1
Haplotype 4 is composed of alleles 2-2.
TR = number of transmitted haplotype 
NT = number of nontransmitted haplotypes
 
.
Asthma
+ Skin Prick Test
TR
NT
X?
TR
NT
X?
AA 50-375
11 
31
38 
0.71
119
128
0.33
12 
3
8
2.27
20
34
3.63
21
41
20
7.23
120
91
3.99
22
4
13
4.76
39
45
0.43
AA 50-406
11 
33
37
0.23
121
131
0.40
12 
2
8
3.60
19
32
3.31
21
40
23
4.59
125
97
3.53
22
5
12
2.88
37
42
0.32
AA 50-411
11 
28
38 
1.52
121
141
1.53
12 
1
1.00
0
1
1.00
21
34
24
1.72
132
112
1.64
22
4
5
0.11
20
19
0.03
AA 50-478
11 
33
35
0.06
118
124
0.15
12 
2
10
5.33
18
34
4.92
21
36
14
9.68
104
82
2.60
22
7
19
5.54
58
58
0.00
AA 50-551
11 
34
40
0.49
128
142
0.73
12 
5
11
2.25
33
42
1.08
21
37
16
8.32
101
79
2.69
22
9
18
3.00
70
69
0.01
AA 375-406
11 
20
5
9.00
67
46
3.90
12 
1
0
1.00
1
4
1.80
21
1
2
0.33
4
8
1.33
22
4
19
9.78
41
55
20.4
AA 375-411
11 
24
9
6.82
87
66
2.88
12 
5
0.00
19
20
0.03
21
4
19
9.78
47
67
3.51
22
0
0
0.00
0
0
0.00
AA 375-478
11 
27
7
11.76
83
62
3.04
12 
3
7
1.60
17
19
0.11
21
--
--
--
2
6
2.00
22
4
20
10.67
43
58
2.23
AA 375-551
11 
28
12
6.40
100
88
0.77
12 
7
8
0.07
41
32
1.11
22
5
20
9.00
47
68
3.83
AA 406-411
11 
23
9
6.12
79
60
2.60
12
4
5
0.11
18
20
0.11
21
5
18
7.35
42
59
2.86
AA 406-478
11 
28
8
11.11
82
63
2.49
12 
4
10
2.57
23
26
0.18
21
1
0
1.00
1
4
1.80
22
4
19
9.78
39
52
1.86
AA 406-551
11 
28
11
7.41
99
88
0.65
12 
7
10
0.53
46
40
0.42
21
1
0
1.00
1
4
1.80
22
9
18
3.00
41
55
2.04
AA 406-2531
11 
--
--
--
64
47
2.60
12 
--
--
--
5
5
0.00
21
--
--
--
42
59
2.86
AA 411-478
11 
26
7
10.94
80
61
2.56
12 
4
21
11.56
43
61
3.12
21
--
--
--
1
3
1.00
22
3
5
0.50
17
16
0.03
AA 411-551
11 
27
11
6.74
102
91
0.63
12 
6
22
9.14
72
82
0.65
21
--
--
--
1
3
1.00
22
5
5
0.00
18
17
0.03
AA 478-551
11 
30
9
11.31
98
87
0.65
12 
2
3
0.20
27
21
0.75
21
0
2
2.00
0
3
3.00
22
7
25
10.12
60
74
1.46

Index of IL4RA Gene results

Complex Trait Mapping in the Hutterites

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